Template-type: ReDif-Paper 1.0 Author-Name: Coccia M. Author-workplace-name: UNU-MERIT Title: Lab-oriented radical innovations as drivers of paradigm shifts in science Abstract: An interesting problem in the economics of innovation and strategic management of labs is to explain the drivers of breakthroughs and paradigm shifts in science. This study confronts the issue by analysing a main case study the technological determinant of the discovery of quasi-periodic materials that has generated a scientific paradigm shift in crystallography. Unlike user-friendly radical innovations, the study here detects some specific radical innovations, defined lab-oriented and adopted by high-skilled users i.e. researchers such as Transmission Electron Microscopy, which tend to support breakthroughs and scientific discoveries. This finding is the foundation for a framework, which endeavours to pinpoint the main characteristics and properties of these strategic lab-oriented radical innovations, which in turn spur scientific advances. Technological analysis of this study explains the critical role of specific technologies supporting knowledge creation and scientific discoveries to understand vital drivers of scientific fields and fruitful linkages that run from technological to scientific progress. Keywords: General Welfare, Technological Change, Research and Development, Intellectual Property Rights Classification-JEL: O30, I31 Series: UNU-MERIT Working Papers Creation-Date: 2014 Number: 2014-090 File-URL: https://unu-merit.nl/publications/wppdf/2014/wp2014-090.pdf File-Format: application/pdf File-Size: 556164 Handle: RePEc:unm:unumer:2014090