Template-type: ReDIF-Paper 1.0 Author-Name: Mahlich, Jörg C. Author-Email: joerg.mahlich@wko.at Author-Workplace-Name: Wirtschaftskammer Österreich Author-Name: Roediger-Schluga, Thomas Author-Email: thomas.roediger@arcs.ac.at Author-Workplace-Name: ARC Systems Research Title: The Determinants of Pharmaceutical R&D Expenditures: Evidence from Japan Abstract: During the past 20 years, the world pharmaceutical industry has experienced a dramatic increase in R&D intensity. We apply and extend a model developed by Grabowski and Vernon (2000) with a pooled data sample of the 15 publicly listed Japanese drug firms for the period 1987 to 1998. As in the reference paper, we find expected returns to be an important determinant of R&D spending in the Japanese drug industry, albeit considerably smaller than in the U.S., which is particularly obvious in the case of returns from newly introduced drugs. However, our results are sensitive to econometric model specification, in particular to controlling for serial correlation and to a dynamic specification of the baseline model. Likewise, estimates on financial constraints are sensitive to model specification, indicating that Japanese drug firms face small or no financial constraints. Our results are consistent with the general literature on R&D investment behaviour, yet raise some methodological questions with regard to the original study. Classification-JEL: L65, O31, O33 Keywords: R&D, investment, panel data estimation, pharmaceuticals, Japan Series: UNU-MERIT Working Papers Creation-Date: 2006 Number: 015 File-URL: http://www.merit.unu.edu/publications/wppdf/2006/wp2006-015.pdf File-Format: application/pdf File-Size: 275 Kb Handle: RePEc:unm:unumer:2006015